Irritable bowel syndrome (IBS) affects 10–15% of the U.S. population and accounts for up to half 
of all gastroenterology referrals, reflecting its significant clinical and societal impact. Emerging 
evidence highlights a multifactorial pathophysiology involving altered motility, visceral 
hypersensitivity, gut–brain axis dysregulation, microbiome disturbances, and dietary triggers. 
With nearly 50% of patients turning to complementary and alternative medicine due to 
persistent symptoms and low treatment satisfaction, nutrition-focused strategies and 
nutraceutical therapies have gained prominence. This session provides an evidence-based 
review of key nutraceuticals— including Traditional Chinese Medicine formulations, Iberogast, 
peppermint oil, artichoke leaf extract, curcumin, antimicrobial botanicals, probiotics, and 
melatonin—alongside dietary interventions such as the gluten-free diet, elimination diets, and 
the low-FODMAP approach. Attendees will learn to evaluate the mechanisms, efficacy data, and 
clinical applications of these therapies to support more individualized, integrative management 
of IBS.

Learning Objectives

By the end of this session, participants will be able to:
1. Explain the pathophysiology and root causes of IBS, including physiologic, psychological, 
microbial, and dietary contributions.
2. Describe the mechanisms of action of nutraceuticals commonly used by IBS patients.
3. Critically appraise the current evidence for and against the use of specialized diets and 
nutraceutical supplements in the management of IBS