Biotics Research Corporation Blog

D and K for Healthy Bones

Biotics Research Blog - April 17, 2019 - 6:40am

We know a lot about vitamin D and bone health. Vitamin D is considered a “secosteroid hormone” essential for calcium absorption and bone mineralization, and is positively associated with bone mineral density (BMD). Without it, we cannot effectively absorb calcium, which we need to help maintain healthy teeth and bones. Also, in a recent study in Annals of Saudi Medicine, vitamin D levels were shown to directly impact BMD. Data was collected on 400 participants where 25OHD levels were taken as well as BMD measurements. What they found came as no surprise; adequate levels of vitamin D had a positive correlation on bone mass among all age groups. 

But what do we know about vitamin K? In addition to vitamin D, vitamin K is another bone-building vitamin. Vitamin K is a fat-soluble vitamin first identified in a study on blood coagulation by Carl Peter Henrik in Denmark. The letter “K” stands for “Koagulation’, a Danish term for coagulation. Vitamin K falls into two types: vitamin K1 and vitamin K2. Vitamin K1 is also known as phylloquinone or phytonadione, and vitamin K2, menaquinone. Different types of vitamin K vary in their biological activities. Vitamin K1 is mainly stored in the liver and plays a greater role in production of coagulation proteins, while vitamin K2 is distributed throughout the whole body. Most of our leafy greens are high in vitamin K and include kale, mustard greens, swiss chard, and spinach.

Abbreviated Topography of Major Landmarks in Our Knowledge of Vitamin D3, Cholecalciferol

Biotics Research Blog - April 9, 2019 - 7:35am

The human nutrient vitamin D3 (cholecalciferol) is essential for life and—as is common with nutrients—plays important roles in many aspects of physiology, including the functioning of numerous cells and tissues in various organs and systems, including the immune system, nervous system, cardiovascular system, gastrointestinal system including the gut microbiome, the latter of which can be considered an extracorporeal metabolic organ with body-wide connections and impact.

Vitamin D’s Critical Role in Weight Management

Biotics Research Blog - April 2, 2019 - 9:04am

When undergoing a weight management program, one of the first steps might be to check vitamin D levels. Oftentimes, people who need to lose weight simultaneously experience low energy, which may actually be a symptom of blood sugar dysregulation. And, according to some researchers, vitamin D may provide support for helping regulate blood sugars. 

The Impact and Benefits of Vitamin D

Biotics Research Blog - March 26, 2019 - 9:10am
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Vitamin D is regarded as one of the most important nutrients for our health. It regulates more than 2,000 of the 30,000 human genes and plays a significant role in immune function and physical performance. Vitamin D also helps the body absorb calcium, subsequently helping build bones and keep them strong and healthy.

Many people hear “vitamin D” and think of exposure to the sun. This is an accurate correlation, as vitamin D is produced in your skin in response to sunlight. However, if you live in non-equatorial latitudes, the sun may not be strong enough to produce vitamin D for about half of the year. In fact, as many as one billion people worldwide are estimated to be vitamin D-deficient. Sustained levels of vitamin D deficiency can result in brittle bones, bone pain, as well as muscle pain and weakness.

So, how does vitamin D impact normal body functioning? What’s the impact on those who rely on superior strength and muscle function, like professional athletes? What can be done to support healthy levels of vitamin D?


Biotics Research Blog - March 12, 2019 - 1:02pm

Have you ever wondered by pimples and constipation often come together, or why you break out after eating french fries? It could be because of the gut-skin axis, a concept at the center of an emerging, exciting area of research in Western Medicine. The gut-skin axis deals with the bidirectional relationship between the gut and the skin, two complex immune and neuroendocrine organs that are host to a varied community of microbes, as well as being related in purpose and function.

However, the gut-skin axis is not a new concept. Over 70 years have passed since dermatologists John H. Stokes and Donald M. Pillsbury discovered a connection between mental health conditions and skin issues, and concluded that a gastrointestinal mechanism could be behind it. They hypothesized that emotional states might alter intestinal flora, cause intestinal permeability and create systemic inflammation.

Title: New Frontiers in Fish Oil - Part Two

Biotics Research Blog - March 5, 2019 - 8:30am

This is part two of a two-part series on omega-3 fatty acids and fish oil. In part one, we explored the reasons to take fish oil.

Throughout evolution, humans have consumed diets heavy in fish—meeting their dietary need for not only omega-3, but specifically EPA and DHA. Western diets, however, have evolved to where fish consumption is at a staggering low. These physiologically-essential nutrients that were once readily available—and consumed often—have become a nutritional deficit for many. Thus, a supplemental dietary solution was needed. That solution is fish oil.

According to the National Institute of Health, fish oil is the most popular natural product used by adults in the United States. Annual sales clock in at about $1.2 billion—three times greater than glucosamine, the number two highest selling natural product. With the continued surge in fish oil’s popularity, it’s more important than ever to keep a close eye on quality. Let’s look at the dilemma facing fish oil producers and what consumers need to know to choose the best quality fish oil for their dietary needs.

New Frontiers in Fish Oil - Part One

Biotics Research Blog - February 26, 2019 - 3:12pm

This is part one of a two-part series on the benefits of omega-3 fatty acids and fish oil. Stay tuned for part two about how to incorporate fish oil into a regular diet.

From supporting cardiovascular health to promoting ideal body composition to optimizing inflammatory pathways, omega-3’s substantive impact on a wide variety of health issues has been well-documented. Here, we take a closer look at this versatile nutrient and its many applications.

Why Take Omega-3 Fatty Acids?

Many research articles support the benefits of omega-3 fatty acids—primarily for their ability to act as the body’s natural protection. For those patients recovering from a heart attack, for example, omega-3 fatty acids aid in the healing process by helping with cardiac remodeling and enabling the heart to contract better. Omega-3 fatty acids also manage the fibrosis in the region and impact the reduction of biomarkers for inflammation. Further, according to the Journal of the American Medicine Association, omega-3 fatty acids also reduce the risk for cardiovascular disease, as well.

Eat Your Thylakoids!

Biotics Research Blog - February 19, 2019 - 9:11am

Most nutrition experts agree that we need to “eat more veggies” as part of a healthy diet.  Consuming more leafy greens (spinach, kale, collards, etc) may, in fact, be one of the most important components for overall health and weight loss. In addition to containing a host of fibers, vitamins, minerals and other micronutrients, leafy greens also have structures called thylakoids, which have been shown to manage cravings and increase satiety. So, the next time you add a side-salad to your lunch, you may also be helping yourself avoid the munchies later on.

Thylakoids are the photosynthetic membranes of chloroplasts that are found in the leaves of green plants. They are appearing on the health and research scene as a promising functional ingredient that exhibits a lipase-inhibiting effect leading to a reduced appetite. Thylakoids include both proteins and lipids (mainly omega-3s), 50% of each. They also contain chlorophyll, antioxidants, carotenoids, and vitamin E.

5 Surprising Things that Hurt Your Microbiome

Biotics Research Blog - February 12, 2019 - 12:49pm

The human gut contains trillions of bacteria – also referred to as the gut flora or microbiome – and these tiny unicellular organisms play an unfathomable role in overall health. For instance, a healthy gut flora has been shown to improve gut health, heart health, brain health, weight management and blood sugar regulation, among others.

Astragalus: The King of Herbs

Biotics Research Blog - February 6, 2019 - 10:22am

Astragalus, also known as Milkvetch or huáng qí in Chinese, is an herb that has been used for hundreds of years, with its roots in traditional Chinese medicine. One of the few all-purpose herbs used, it is believed to support a wide array of biological functions.  

Despite the fact that Astragalus has over 2,000 species, only two are principally used in supplementsAstragalus mongholicus and Astragalus membranaceus. The main part of the plant utilized for medicinal purposes is its roots, which can be made into powders, capsules and liquid extracts.

Pharmacological research has shown that the extract of Astragalus membranaceus can be quite beneficial, as it increase telomerase activity, and has immunoregulatory, antihyperglycemic, hypolipidemic, diuretic, antioxidant and anti-inflammatory effects.

Sleep and DNA Methylation

Biotics Research Blog - January 29, 2019 - 12:07pm

A recent study led by Jonathan Cedernaes and  researchers at Uppsala University reported that the consequences of acute sleep loss on weight gain are more than being hungry and making poor food choices. They demonstrated “how” sleep loss, shift work or sleep disturbances influence the epigenome and gene expression through DNA methylation.

Numerous studies suggest that shift workers are more likely to become overweight or obese from acute circadian misalignment. While there is not a magic number of hours of sleep for reduced risk of metabolic conditions such as type 2 diabetes, one meta-analysis found the lowest risk at 7-8 hours of sleep per day, while short or long sleep increased the risk. In the last century it is no coincidence that America has seen an increase in numerous chronic illnesses as well as an approximate 20% decrease in the amount of sleep it gets. Current research also supports the role of sleep deprivation as part of the current obesity trend in children. Some obvious reasons may be the negative impact of insufficient sleep on eating behaviors and activity levels. Sleep even reduces the benefits of dieting – while the scale may show the same weight loss from a full night’s sleep or less sleep, the later reduced fat loss by 55%. While many dieters pay strict attention to meal planning and food preparation, they must also consider the quality/duration of their sleep to obtain the desired effects of a diet.

Spice Up Your Microbial Health

Biotics Research Blog - January 22, 2019 - 10:37am

Among the many herbs and spices used to foster gut health is oregano. Derived from the Greek words “oros” (meaning mountain) and “ganos” (meaning joy), oregano was supposedly grown by the Greek goddess Aphrodite as a symbol of joy. Most known for its aromatic use in culinary dishes, oregano also has a history of medicinal application. As a matter of fact, many culinary herbs used for flavoring are important sources of micronutrients, which benefit overall health.

Exercise Your Guts Out

Biotics Research Blog - January 15, 2019 - 3:17pm

Exercise is good for us, yes? With its wide-range of benefits that include supporting heart, muscle and bone health, the short answer is yes. But could there be repercussions in over-exercising? For some people, yes; intense exercise can lead to leaky gut. In the literature, it is referred to as “exercise-induced gut permeability,” and the mechanism for damage stems from changes in blood flow and neuronal functioning. During exercise, blood flow is diverted from the intestinal tract. Also, changes in the nervous system work to decrease intestinal motility. Our bodies move the resources to the arms and legs, and away from the gastrointestinal (GI) tract. Similarly, stress of any kind can exacerbate leaky gut for the same reason. Adrenal hormones move resources away from the GI tract and into skeletal muscle, away from the intestines. In addition, any type of stress can cause oxidative damage.

Impact of Diet on Baby’s Microbiome

Biotics Research Blog - January 8, 2019 - 10:17am

Whether you’re a would-be parent or your newborn is already safely in your arms, the joy and wonder of having a new member in your family can be truly exhilarating. But what most parents may not take the time to think about is the impact a baby’s diet has on their microbiome.

The importance of developing a healthy gut flora from early life stages cannot be overemphasized. Among other things, a healthy microbiome helps to boost immune functioning, aids digestion and improves nutrient absorption. These, of course, lead to overall health. However, babies aren’t born with a fully-developed microbial colony, but if properly developed, the microbiome can lay a valuable foundation for a healthy life.

Do You Have Leaky Brain?

Biotics Research Blog - January 2, 2019 - 7:40pm

The NIH estimates that 20% of Americans have a diagnosable mental disorder, at a cost of $201 billion per year. The most common maladies are depression and phobias. In 2014, the CDC issued a report indicating that the U.S. suicide rate reached 13 per 100,000, the highest it had been since 1986. We are beginning to look at systemic inflammation and its effect on the blood-brain barrier as a cause of neurodegeneration and, subsequently, mental health problems. The blood-brain barrier (BBB) is semi-permeable and vulnerable to damage by free radicals and inflammation.  

As for the efficacy of antidepressants, a report published in Psychotherapy and Psychosomatics states, “Meta-analyses of FDA trials suggest that antidepressants are only marginally efficacious compared to placebos.” Because of this, researchers continue to explore mechanisms to address mental health issues. Scientists are now exploring how inflammation might decrease the firing rate of neurons in the frontal lobe of the brain in people with depression. Some believe that medications used to manage depression are limited since they do not address underlying brain inflammation.